Developmental programming: impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics
نویسندگان
چکیده
منابع مشابه
Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.
Prenatal T excess induces maternal hyperinsulinemia, early puberty, and reproductive/metabolic defects in the female similar to those seen in women with polycystic ovary syndrome. This study addressed the organizational/activational role of androgens and insulin in programming pubertal advancement and periovulatory LH surge defects. Treatment groups included the following: 1) control; 2) prenat...
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Background: Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Materials and Methods: Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in ...
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ژورنال
عنوان ژورنال: Journal of Developmental Origins of Health and Disease
سال: 2012
ISSN: 2040-1744,2040-1752
DOI: 10.1017/s2040174412000128